In-Vivo Evaluation of Severity of Microvascular Impairments and Epicardial Coronary Stenoses Using Fundamental Fluid Dynamics Endpoints Available to Purchase

Coronary circulation is mainly regulated by two serial resistances, namely, epicardial stenosis and microvascular impairments, both causing abnormal coronary blood circulation [1]. Delineation of the true severities of these diseases is important to guide clinical decision-making processes for the selection of appropriate treatment procedures [2]. The presently used diagnostic parameters: FFR (fractional flow reserve defined as the ratio of distal to proximal hyperemic pressure) and CFR (coronary flow reserve defined as ratio of basal to hyperemic flow) [1], for the evaluation of severity of epicardial coronary stenosis are well established in clinical practice. On the other hand, current methods to evaluate the microcirculatory status are limited [3].