Osteoarthritis (OA) of the knee affects an estimated 20–40% of individuals over the age of 65 [1], and is nearly 10 times more common in the medial compartment than the lateral compartment [2]. Plain radiography measurements using the Kellgren and Lawrence (KL) scale have been the gold standard for diagnosis of knee osteoarthritis [3]. However, for new treatment interventions for medial compartment knee OA such as load modifying footwear, it would be important to know if the disease-related cartilage loss in the medial compartment occurs initially and predominantly in regions that are weight bearing during walking. Because walking results in highest weight bearing occurring in the anterior and middle regions of the femoral condyle and the anterior region of the tibial plateau, seeing a pattern of thinning in these areas would suggest that walking is an important activity for understanding both the cause and treatment of osteoarthritis.
Skip Nav Destination
ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Regional Cartilage Thinning Occurs First in the Walking Weight Bearing Regions of the Femur in Medial Compartment Knee Osteoarthritis
Jennifer C. Erhart,
Jennifer C. Erhart
Stanford University, Stanford, CA
VA Palo Alto Health Care System, Palo Alto, CA
Search for other works by this author on:
Anne Mündermann,
Anne Mündermann
Stanford University, Stanford, CA
VA Palo Alto Health Care System, Palo Alto, CA
University of Otago, Dunedin, New Zealand
Search for other works by this author on:
Seungbum Koo,
Seungbum Koo
Stanford University, Stanford, CA
Search for other works by this author on:
Ben Merrick,
Ben Merrick
Stanford University, Stanford, CA
Search for other works by this author on:
Andrew Deagon,
Andrew Deagon
Stanford University, Stanford, CA
Search for other works by this author on:
Nicholas J. Giori,
Nicholas J. Giori
VA Palo Alto Health Care System, Palo Alto, CA
Stanford University, Stanford, CA
Search for other works by this author on:
Thomas P. Andriacchi
Thomas P. Andriacchi
Stanford University, Stanford, CA
VA Palo Alto Health Care System, Palo Alto, CA
Search for other works by this author on:
Jennifer C. Erhart
Stanford University, Stanford, CA
VA Palo Alto Health Care System, Palo Alto, CA
Anne Mündermann
Stanford University, Stanford, CA
VA Palo Alto Health Care System, Palo Alto, CA
University of Otago, Dunedin, New Zealand
Seungbum Koo
Stanford University, Stanford, CA
Ben Merrick
Stanford University, Stanford, CA
Andrew Deagon
Stanford University, Stanford, CA
Nicholas J. Giori
VA Palo Alto Health Care System, Palo Alto, CA
Stanford University, Stanford, CA
Thomas P. Andriacchi
Stanford University, Stanford, CA
VA Palo Alto Health Care System, Palo Alto, CA
Paper No:
SBC2008-192015, pp. 835-836; 2 pages
Published Online:
March 13, 2014
Citation
Erhart, JC, Mündermann, A, Koo, S, Merrick, B, Deagon, A, Giori, NJ, & Andriacchi, TP. "Regional Cartilage Thinning Occurs First in the Walking Weight Bearing Regions of the Femur in Medial Compartment Knee Osteoarthritis." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 835-836. ASME. https://doi.org/10.1115/SBC2008-192015
Download citation file:
3
Views
Related Proceedings Papers
Related Articles
Experimental Studies on Repair of Large Osteochondral Defects at a High Weight Bearing Area of the Knee Joint: A Tissue Engineering Study
J Biomech Eng (May,1991)
Related Chapters
Sensitive Quantitative Predictions of MHC Binding Peptide from Entamoeba Histolytica
International Conference on Software Technology and Engineering, 3rd (ICSTE 2011)
Effects of Rotational Ellipsoidal Acetabular Cartilage Surface's Axis Length Ratio on the Contact Stress in the Hip
International Conference on Mechanical and Electrical Technology, 3rd, (ICMET-China 2011), Volumes 1–3
Effects of Ultrasound Stimulation on Chondrocytes in Three-Dimensional Culture in Relation to the Production of Regenerative Cartilage Tissue
Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling