Stroke is the third leading cause of death and a major cause of disability in the United States. Extracranial carotid artery disease is a major risk factor for stroke. Local hemodynamic forces are important in the development and progression of atherogenesis with areas of low and oscillatory wall shear stress (WSS) such as those occurring in the carotid bifurcation being more prone to atheroma development. Despite the importance of WSS in atherosclerosis, there is currently no practical means of measuring this variable clinically. Computational fluid dynamics (CFD) simulations of patient-specific models built from imaging data may provide a clinically relevant solution [1]. For CFD results to be clinically applicable, they need to replicate hemodynamic and imaging measurements to provide physiologic WSS values and the simulation and quantification process must be conducted in a time-frame consistent with the short duration needed for plaque and intima-media thickness assessment. LaDisa, Migrino and colleagues recently reported on a rapid and practical means of generating WSS maps associated with carotid atherosclerosis using patient-specific CFD models derived from 2D and Doppler ultrasound for flow information and MRI for 3D structure before and after 6 months of statin treatment [2]. Although these results were achieved after 17±8 hours/patient instead of days or weeks for prior models, model construction, quantification of results and simulation time were the most time consuming portions of the simulation process with CFD model construction being the most user-intensive portion of the process.
Skip Nav Destination
Close
Sign In or Register for Account
ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Modeling and Realistic Simulation of the Carotid Artery Birfurcation Using 3-D Image Segmentation Implemented in a Commercial Software Package for Hemodynamic Simulation (cvSim™)
Nathan M. Wilson,
Nathan M. Wilson
Cardiovascular Simulation, Inc., Mountain View, CA
Search for other works by this author on:
Raymond Q. Migrino,
Raymond Q. Migrino
Medical College of Wisconsin, Milwaukee, WI
Search for other works by this author on:
Leanne Harmann,
Leanne Harmann
Medical College of Wisconsin, Milwaukee, WI
Search for other works by this author on:
Robert W. Prost,
Robert W. Prost
Medical College of Wisconsin, Milwaukee, WI
Search for other works by this author on:
John F. LaDisa, Jr.
John F. LaDisa, Jr.
Medical College of Wisconsin, Milwaukee, WI
Marquette University, Milwaukee, WI
Search for other works by this author on:
Nathan M. Wilson
Cardiovascular Simulation, Inc., Mountain View, CA
Raymond Q. Migrino
Medical College of Wisconsin, Milwaukee, WI
Leanne Harmann
Medical College of Wisconsin, Milwaukee, WI
Robert W. Prost
Medical College of Wisconsin, Milwaukee, WI
John F. LaDisa, Jr.
Medical College of Wisconsin, Milwaukee, WI
Marquette University, Milwaukee, WI
Paper No:
SBC2008-193258, pp. 797-798; 2 pages
Published Online:
March 13, 2014
Citation
Wilson, NM, Migrino, RQ, Harmann, L, Prost, RW, & LaDisa, JF, Jr. "Modeling and Realistic Simulation of the Carotid Artery Birfurcation Using 3-D Image Segmentation Implemented in a Commercial Software Package for Hemodynamic Simulation (cvSim™)." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 797-798. ASME. https://doi.org/10.1115/SBC2008-193258
Download citation file:
- Ris (Zotero)
- Reference Manager
- EasyBib
- Bookends
- Mendeley
- Papers
- EndNote
- RefWorks
- BibTex
- ProCite
- Medlars
Close
Sign In
4
Views
0
Citations
Related Proceedings Papers
Related Articles
Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells Exposed to Physiological Coronary Wall Shear Stresses
J Biomech Eng (August,2009)
Particle-Hemodynamics Simulations and Design Options for Surgical Reconstruction of Diseased Carotid Artery Bifurcations
J Biomech Eng (April,2004)
Deformable Mock Stenotic Artery With a Lipid Pool
J Biomech Eng (March,2010)
Related Chapters
Mri Image Segmentation Based on FCM Clustering Using an Adaptive Threshold Algorithm
International Conference on Computer Technology and Development, 3rd (ICCTD 2011)
Brain Tissue Segmentation in MRI Images Using Random Forest Classifier and Gossip Based Neighborhood
International Conference on Computer Technology and Development, 3rd (ICCTD 2011)
Pixel Run Length Based Adaptive Region Growing (PRL-ARG)Technique for Segmentation of Tumor from MRI Images
International Conference on Computer and Electrical Engineering 4th (ICCEE 2011)