We introduce a lensfree on chip imaging platform that enables high-throughput monitoring, counting, and identification of several different microscopic objects such as different cell types within a heterogeneous solution. This imaging platform can in principle be miniaturized to a hand-held device that can be used by minimally trained health care providers at the point-of-care to measure the cell count of e.g., red blood cells from whole blood samples with a counting speed of >100,000 cells/sec. This novel optical imaging platform can also be merged with microfluidic systems to be able to rapidly monitor and count hundreds of thousand of cells within a field-of-view (FOV) of ∼10 cm2 in vitro. The immediate impact of this lensfree on chip cell counting approach is its improved speed, significantly larger field-of-view and simplified design that permits considerable miniaturization of the entire cell counting device.
- Bioengineering Division
High-Throughput Cell Imaging, Counting and Characterization on a Chip
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Su, T, Seo, S, Erlinger, A, & Ozcan, A. "High-Throughput Cell Imaging, Counting and Characterization on a Chip." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 795-796. ASME. https://doi.org/10.1115/SBC2008-193255
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