The architecture of the vascular wall is highly intricate and requires unique biomechanical properties in order to function properly. Native artery is composed of a mix of collagens, elastin, endothelial cells (ECs), smooth muscle cells (SMC), fibroblasts, and proteoglycans arranged into three distinct layers: the intima, media, and adventitia. Throughout artery, collagen and elastin play an important role, providing a mechanical backbone, preventing vessel rupture, and promoting recovery while undergoing pulsatile deformations [1]. The low-strain mechanical response of artery to blood flow is dominated by the elastic behavior, of elastin, which prevents pulsatile energy from being dissipated as heat [2]. A higher amount of energy loss indicates a decrease in recoverability, which could lead to eventual disruption of blood flow. An effective way to quantify recoverability is through hysteresis and compliance measurement. The hypothesis of this study was that the fabrication of a multi-layered electrospun tissue engineering scaffold composed of polycaprolactone (PCL), elastin, and collagen would demonstrate dynamic mechanical properties indicative of a highly elastic material, similar to the three distinct layers of native arterial tissue, while remaining conducive to tissue regeneration. PCL was chosen, in this case, to provide mechanical integrity and elasticity, while elastin and collagen would provide further elasticity and bioactivity [3,4].

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