Cerebral aneurysms are an important cerebrovascular condition because aneurysm rupture is the most common cause of subarachnoid hemorrhage, which has a high mortality rate and a poor prognosis. Since the mechanism of cerebral aneurysm pathogenesis has not yet been understood, the preventative treatment for unruptured aneurysms is surgery only; however, the morbidity of the surgery is as high as over 10% [1]. On the other hand, the annual risk of rupture of cerebral aneurysms is not so high, reported to be 1.9% [2]. Consequently, it is difficult to judge whether a patient with an unruptured cerebral aneurysm should undergo surgery, when it is detected. Thus, it is important to develop a better understanding of the mechanism of cerebral aneurysm pathogenesis.

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