The low patency rates of Arteriovenous (AV) fistulae are well documented in the literature [1]. Up to 90% of AV fistula morbidity is caused by stenotic lesion formation and the subsequent development of thrombosis in the Vascular Access (VA) junction [1]. The underlying pathology of these stenotic lesions is intimal hyperplasia (IH) which has been characterized by the degradation of the extra cellular matrix (ECM), migration and proliferation of smooth muscle cells (SMCs) and the infiltration of leukocytes and monocytes into the intima. IH primarily occurs in a number of key locations within the VA junction of AV fistulae which include the suture line of the anastomosis, on the floor of the vein opposite the VA junction and downstream of the anastomosis within the venous conduit of the AV fistula [2].
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
The Influence of Realistic Arteriovenous (AV) Fistula Wall Shear Stress (WSS) on Endothelial Cell (EC) Gene Expression: A Correlation to Intimal Hyperplasia Development
Gráinne T. Carroll,
Gráinne T. Carroll
University of Limerick, Limerick, Ireland
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Paul D. Devereux,
Paul D. Devereux
University of Limerick, Limerick, Ireland
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Anthony Callanan,
Anthony Callanan
University of Limerick, Limerick, Ireland
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Tim M. McGloughlin,
Tim M. McGloughlin
University of Limerick, Limerick, Ireland
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Michael T. Walsh
Michael T. Walsh
University of Limerick, Limerick, Ireland
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Gráinne T. Carroll
University of Limerick, Limerick, Ireland
Paul D. Devereux
University of Limerick, Limerick, Ireland
Anthony Callanan
University of Limerick, Limerick, Ireland
Tim M. McGloughlin
University of Limerick, Limerick, Ireland
Michael T. Walsh
University of Limerick, Limerick, Ireland
Paper No:
SBC2008-193248, pp. 69-70; 2 pages
Published Online:
March 13, 2014
Citation
Carroll, GT, Devereux, PD, Callanan, A, McGloughlin, TM, & Walsh, MT. "The Influence of Realistic Arteriovenous (AV) Fistula Wall Shear Stress (WSS) on Endothelial Cell (EC) Gene Expression: A Correlation to Intimal Hyperplasia Development." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 69-70. ASME. https://doi.org/10.1115/SBC2008-193248
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