The onset of arthritis is clearly associated with abnormal joint kinematics and contact pressures [1]. Yet our understanding of in vivo joint mechanics is still limited. In order to elucidate the relationship between joint mechanics and arthritis we must increase our knowledge of normal contact pressure distributions that help maintain healthy cartilage and abnormal contact pressure distributions that lead to arthritis. MRI-based modeling is a non-invasive means of determining joint mechanics in vivo, by combining information from MRI scans of joints with and without active functional loading.

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