The accurate characterization of living cell micro-mechanical properties is a clinically important problem since several disease pathologies depend on the deformation response of cells to applied mechanical loads. For example, the acute respiratory distress syndrome (ARDS) is characterized by an increase in the permeability of the alveolar-capillary barrier, resulting in an influx of edema fluid into the lung. Due to the surfactant inactivation and decreased gas exchange, ARDS patients must be mechanically ventilated [1,3]. However, hydrodynamic stresses exerted on the epithelial cells (EpC) that line airway walls during the reopening of the collapsed or fluid-filled airways can lead to further injury known as ventilator-induced lung injury [1].
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Accuracy of Cell Mechanical Measurements Using Oscillating Optical Tweezers: A Computational Study
Laura M. Ricles,
Laura M. Ricles
Lehigh University, Bethlehem, PA
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Hannah L. Dailey,
Hannah L. Dailey
Lehigh University, Bethlehem, PA
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Samir N. Ghadiali
Samir N. Ghadiali
Lehigh University, Bethlehem, PA
Search for other works by this author on:
Laura M. Ricles
Lehigh University, Bethlehem, PA
Hannah L. Dailey
Lehigh University, Bethlehem, PA
Samir N. Ghadiali
Lehigh University, Bethlehem, PA
Paper No:
SBC2008-192872, pp. 495-496; 2 pages
Published Online:
March 13, 2014
Citation
Ricles, LM, Dailey, HL, & Ghadiali, SN. "Accuracy of Cell Mechanical Measurements Using Oscillating Optical Tweezers: A Computational Study." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 495-496. ASME. https://doi.org/10.1115/SBC2008-192872
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