Current Aortic Valve (AV) computational structural models do not explicitly account for the layered leaflet microstructure, i.e. collagen fibers and elastin matrix. Homogenized anisotropic hyperelastic material models are commonly used for the effective mechanical behavior of the leaflets. The later are difficult to calibrate and often unstable in structural simulations. In this study, we introduce a new heterogeneous material micromodeling approach for the porcine leaflet tissue that explicitly recognizes the collagen fiber network (CFN) distribution and integrate it with the elastin matrix into the global structural analysis of the AV system. The proposed multiscale (heterogeneous) material and structural (MMS) models are verified in their ability to predict the overall AV structural response from in-vitro pulsatile and static loops. Sophisticated imagery measurements are used to examine the kinematics and deformations of the leaflets. The proposed MMS framework is computationally effective in predicting the overall mechanical behavior of the AV structure.
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Multiscale Structural Analysis of Porcine Aortic Heart Valves Using a Collagen Fiber Network (CFN) Micromodel
Hee Sun Kim,
Hee Sun Kim
Georgia Institute of Technology, Atlanta, GA
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Choon Hwai Yap,
Choon Hwai Yap
Georgia Institute of Technology/Emory University, Atlanta, GA
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Lakshmi Prasad Dasi,
Lakshmi Prasad Dasi
Georgia Institute of Technology/Emory University, Atlanta, GA
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Ajit P. Yoganathan,
Ajit P. Yoganathan
Georgia Institute of Technology/Emory University, Atlanta, GA
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Rami Haj-Ali
Rami Haj-Ali
Georgia Institute of Technology, Atlanta, GA
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Hee Sun Kim
Georgia Institute of Technology, Atlanta, GA
Choon Hwai Yap
Georgia Institute of Technology/Emory University, Atlanta, GA
Lakshmi Prasad Dasi
Georgia Institute of Technology/Emory University, Atlanta, GA
Ajit P. Yoganathan
Georgia Institute of Technology/Emory University, Atlanta, GA
Rami Haj-Ali
Georgia Institute of Technology, Atlanta, GA
Paper No:
SBC2008-192800, pp. 451-452; 2 pages
Published Online:
March 13, 2014
Citation
Kim, HS, Yap, CH, Dasi, LP, Yoganathan, AP, & Haj-Ali, R. "Multiscale Structural Analysis of Porcine Aortic Heart Valves Using a Collagen Fiber Network (CFN) Micromodel." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 451-452. ASME. https://doi.org/10.1115/SBC2008-192800
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