Mechanical Stimulation Induced Elastogenesis in Collagenous Scaffolds Seeded With Bladder Smooth Muscle Cells

The most successful approaches to tissue engineering the urinary bladder utilize biodegradable scaffolds seeded with autologous cells. Although this technique has proven successful in increasing bladder capacity, problems remain with lack of proper tissue organization post-implantation, impairing the bladder’s ability to maintain its full function. Small intestinal submucosa (SIS) has been utilized previously to engineer the urinary bladder wall with and without cell seeding.