Hemodynamic factors are thought to play an important role in the initiation, growth, and rupture of cerebral aneurysms. In-vitro studies have demonstrated a correlation between the magnitude and distribution of wall shear stress (WSS) and biological response of both endothelial cells and smooth muscle cells [1–3]. In elastase induced saccular aneurysms, low WSS (below 0.5 Pa) was found to have a correlation with altered expression of biological markers [4]. Localized regions of rapid aneurysm growth in-vivo have been shown to be associated with regions where WSS is below a critical value of 0.1 Pa [5]. Further, aspect ratio (AR), the ratio of the maximum diameter of the aneurysm to the width of the aneurysm neck, has been correlated with elevated risk of rupture [6]. The purpose of the current study is to explore the possibility of creating elastase induced aneurysms in rabbits with a range of aspect ratios (ratio of aneurysm height/neck) and evaluate the existence of a correlation between aspect ratio and WSS distribution. Aneurysms with ARs from 0.98 to 2.8 were created at the origin of the right common carotid artery (n = 30). Qualitative differences in WSS distribution were found in the high AR aneurysms (HARA) (AR>1.6) and low AR aneurysms (LARA) (AR<1.6) [7].
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
CFD Study of the Relationship Between Wall Shear Stress and Aspect Ratio in Elastase Induced Rabbit Aneurysm Models
Zijing Zeng,
Zijing Zeng
University of Pittsburgh, Pittsburgh, PA
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Hasballah Zakaria,
Hasballah Zakaria
University of Pittsburgh, Pittsburgh, PA
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Ramanathan Kadirvel,
Ramanathan Kadirvel
Mayo Clinic College of Medicine, Rochester, MN
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Yong-Hong Ding,
Yong-Hong Ding
Mayo Clinic College of Medicine, Rochester, MN
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Debra A. Lewis,
Debra A. Lewis
Mayo Clinic College of Medicine, Rochester, MN
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David F. Kallmes,
David F. Kallmes
Mayo Clinic College of Medicine, Rochester, MN
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Anne Marie Robertson
Anne Marie Robertson
University of Pittsburgh, Pittsburgh, PA
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Zijing Zeng
University of Pittsburgh, Pittsburgh, PA
Hasballah Zakaria
University of Pittsburgh, Pittsburgh, PA
Ramanathan Kadirvel
Mayo Clinic College of Medicine, Rochester, MN
Yong-Hong Ding
Mayo Clinic College of Medicine, Rochester, MN
Debra A. Lewis
Mayo Clinic College of Medicine, Rochester, MN
David F. Kallmes
Mayo Clinic College of Medicine, Rochester, MN
Anne Marie Robertson
University of Pittsburgh, Pittsburgh, PA
Paper No:
SBC2008-193139, pp. 35-36; 2 pages
Published Online:
March 13, 2014
Citation
Zeng, Z, Zakaria, H, Kadirvel, R, Ding, Y, Lewis, DA, Kallmes, DF, & Robertson, AM. "CFD Study of the Relationship Between Wall Shear Stress and Aspect Ratio in Elastase Induced Rabbit Aneurysm Models." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 35-36. ASME. https://doi.org/10.1115/SBC2008-193139
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