Changes in medial elastin are critical to arterial remodeling following a sustained increase in blood flow, wherein the lumen enlarges in two phases tending to restore the intimal shear stress to control: 1st, via rapid smooth muscle relaxation and, 2nd, via chronic reconstruction of the media . At the same time, wall thickening takes place aiming at restoring the baseline levels of wall stress .
- Bioengineering Division
Arterial Remodeling in Response to Increased Blood Flow Using a Constituent-Based Model
Tsamis, A, & Stergiopulos, N. "Arterial Remodeling in Response to Increased Blood Flow Using a Constituent-Based Model." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 345-346. ASME. https://doi.org/10.1115/SBC2008-192557
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