Kinesins, biomolecular motors that move along microtubules (MTs) can potentially be utilized as an actuator in nanoscale transporting systems. Recent studies have reported inverted geometry in vitro, in which MTs randomly moved on kinesins fixed to substrates. To develop the transporting systems, one of key elements includes precise control of the direction of sliding MTs. One possible method is to utilize electric field (EF) to direct the MTs because MTs are negatively charged in neutral solutions [1,2]. For example, MTs have been shown to orient to the direction of uniaxially or biaxially applied EFs [3,4]. However, for a reliable transporting system, further studies are still required to control the direction of sliding MTs dynamically and effectively. In our previous study [5], we applied EF to MTs in random direction and showed that the rate of change in angle (angular velocity) was proportional to the sin of the angle between the directions of MTs and the generated electrophoretic force. The result indicates that it is most efficient to continuously apply EF perpendicular to the direction of MTs. In this study, the direction of sliding MTs was dynamically controlled with EF, particularly demonstrating a circular movement of MTs.
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Dynamic Control of Sliding Directions of Kinesin-Driven Microtubules With Rotating Electric Fields Available to Purchase
Shukei Sugita,
Shukei Sugita
Tohoku University, Sendai, Japan
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Naoya Sakamoto,
Naoya Sakamoto
Tohoku University, Sendai, Japan
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Toshiro Ohashi,
Toshiro Ohashi
Tohoku University, Sendai, Japan
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Masaaki Sato
Masaaki Sato
Tohoku University, Sendai, Japan
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Shukei Sugita
Tohoku University, Sendai, Japan
Naoya Sakamoto
Tohoku University, Sendai, Japan
Toshiro Ohashi
Tohoku University, Sendai, Japan
Masaaki Sato
Tohoku University, Sendai, Japan
Paper No:
SBC2008-192496, pp. 315-316; 2 pages
Published Online:
March 13, 2014
Citation
Sugita, S, Sakamoto, N, Ohashi, T, & Sato, M. "Dynamic Control of Sliding Directions of Kinesin-Driven Microtubules With Rotating Electric Fields." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 315-316. ASME. https://doi.org/10.1115/SBC2008-192496
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