Ninety-seven percent of tendon ruptures are found in areas of chronic tendon degeneration, which is thought to be a cell-mediated process involving increased extracellular matrix turnover and remodeling [1,2]. The degenerative aspects seen within regions of tendon degeneration include collagen matrix disorganization, collagen fibril thinning, cellular hyperplasia, and neovascularization [1–3]. The etiology of tendon degeneration is unclear at this point. One theory involves the introduction of multiple mechanical insults (mechanical overuse) that act to trigger a degenerative pathway of increased matrix degradation by matrix metalloproteinases (MMP). Inflammation is not seen within regions of degenerative tendon. However, inflammatory mediators such as prostaglandin-E2 (PGE2) may have a role as they have been shown to be upregulated by fibroblasts as a result of mechanical over-stimulation in culture [4]. Multiple injections of PGE2 within the midsubstance of the rabbit patellar tendon (PT) also produced collagen fibril disorganization and thinning [5].
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Comparative Histological and Biomechanical Effects of Prostaglandin-E2 and Bacterial Collagenase on the Rabbit Patellar Tendon Available to Purchase
Nathaniel A. Dyment,
Nathaniel A. Dyment
University of Cincinnati, Cincinnati, OH
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Jason T. Shearn,
Jason T. Shearn
University of Cincinnati, Cincinnati, OH
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Marc T. Galloway,
Marc T. Galloway
Cincinnati Sportsmedicine and Orthopaedic Center, Cincinnati, OH
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R. Michael Greiwe,
R. Michael Greiwe
University of Cincinnati, Cincinnati, OH
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Keith Kenter,
Keith Kenter
University of Cincinnati, Cincinnati, OH
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Samer S. Hasan,
Samer S. Hasan
Cincinnati Sportsmedicine and Orthopaedic Center, Cincinnati, OH
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David L. Butler,
David L. Butler
University of Cincinnati, Cincinnati, OH
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Gregory P. Boivin
Gregory P. Boivin
University of Cincinnati, Cincinnati, OH
Veterans Affairs Medical Center, Cincinnati, OH
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Nathaniel A. Dyment
University of Cincinnati, Cincinnati, OH
Jason T. Shearn
University of Cincinnati, Cincinnati, OH
Marc T. Galloway
Cincinnati Sportsmedicine and Orthopaedic Center, Cincinnati, OH
R. Michael Greiwe
University of Cincinnati, Cincinnati, OH
Keith Kenter
University of Cincinnati, Cincinnati, OH
Samer S. Hasan
Cincinnati Sportsmedicine and Orthopaedic Center, Cincinnati, OH
David L. Butler
University of Cincinnati, Cincinnati, OH
Gregory P. Boivin
University of Cincinnati, Cincinnati, OH
Veterans Affairs Medical Center, Cincinnati, OH
Paper No:
SBC2008-192395, pp. 275-276; 2 pages
Published Online:
March 13, 2014
Citation
Dyment, NA, Shearn, JT, Galloway, MT, Greiwe, RM, Kenter, K, Hasan, SS, Butler, DL, & Boivin, GP. "Comparative Histological and Biomechanical Effects of Prostaglandin-E2 and Bacterial Collagenase on the Rabbit Patellar Tendon." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 275-276. ASME. https://doi.org/10.1115/SBC2008-192395
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