Urethral dysfunction is a common complication of diabetes mellitus, spinal cord injury, vaginal childbirth, and pelvic trauma. Stress urinary incontinence (SUI) is the involuntary loss of urine due to the inability of the urethral sphincter to maintain a tight seal during the storage phase and is a condition that physically and emotionally affects 25 million American women annually [1]. There are currently several treatments for SUI including surgery, Kegel exercises, and electrical stimulation, each accompanied by limited effectiveness and/or complications [2–3]. We believe that regenerative medicine techniques, applied to the native urethra, may aid in improving the function and support of the diseased urethra. Thus, we have begun the development of a tissue engineered urethral wrap (TEUW) for placement as a cuff around the native urethra and integration with the host tissue. The goal of this work was to explore structural and mechanical effects following implantation of a TEUW.
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
In Vivo Effects and Ex Vivo Characteristics Following Implantation of a Tissue Engineered Urethral Wrap
Donna J. Haworth,
Donna J. Haworth
University of Pittsburgh, Pittsburgh, PA
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Minoru Miyazato,
Minoru Miyazato
University of Pittsburgh, Pittsburgh, PA
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Akira Furuta,
Akira Furuta
University of Pittsburgh, Pittsburgh, PA
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Dae Kyung Kim,
Dae Kyung Kim
University of Pittsburgh, Pittsburgh, PA
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Douglas W. Chew,
Douglas W. Chew
University of Pittsburgh, Pittsburgh, PA
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Naoki Yoshimura,
Naoki Yoshimura
University of Pittsburgh, Pittsburgh, PA
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Michael B. Chancellor,
Michael B. Chancellor
University of Pittsburgh, Pittsburgh, PA
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David A. Vorp
David A. Vorp
University of Pittsburgh, Pittsburgh, PA
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Donna J. Haworth
University of Pittsburgh, Pittsburgh, PA
Minoru Miyazato
University of Pittsburgh, Pittsburgh, PA
Akira Furuta
University of Pittsburgh, Pittsburgh, PA
Dae Kyung Kim
University of Pittsburgh, Pittsburgh, PA
Douglas W. Chew
University of Pittsburgh, Pittsburgh, PA
Naoki Yoshimura
University of Pittsburgh, Pittsburgh, PA
Michael B. Chancellor
University of Pittsburgh, Pittsburgh, PA
David A. Vorp
University of Pittsburgh, Pittsburgh, PA
Paper No:
SBC2008-192353, pp. 263-264; 2 pages
Published Online:
March 13, 2014
Citation
Haworth, DJ, Miyazato, M, Furuta, A, Kim, DK, Chew, DW, Yoshimura, N, Chancellor, MB, & Vorp, DA. "In Vivo Effects and Ex Vivo Characteristics Following Implantation of a Tissue Engineered Urethral Wrap." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 263-264. ASME. https://doi.org/10.1115/SBC2008-192353
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