Magnetic nanoparticle hyperthermia has potential to achieve optimal therapeutic results due to its ability to deliver adequate heating power to irregular and/or deep-seated tumor at low magnetic field frequency and amplitude . Iron oxides magnetite Fe3O4 and maghemite γ-Fe2O3 nanoparticles are the most studied to date  due to their biocompatibilty  for hyperthermia application. The heat generated by the particles when exposed to an external alternating magnetic field is mainly due to the Néel relaxation mechanism and/or Brownian motion of the particles . The superparamagnetic particles (10–40 nm) are recommended in clinical application as they are able to generate substantial heat within a small magnetic field strength and frequency .
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An In-Vivo Experimental Study of Temperature Elevations in Animal Tissue During Magnetic Nanoparticle Hyperthermia
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Salloum, M, Ma, R, & Zhu, L. "An In-Vivo Experimental Study of Temperature Elevations in Animal Tissue During Magnetic Nanoparticle Hyperthermia." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 251-252. ASME. https://doi.org/10.1115/SBC2008-192321
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