Magnetic nanoparticle hyperthermia has potential to achieve optimal therapeutic results due to its ability to deliver adequate heating power to irregular and/or deep-seated tumor at low magnetic field frequency and amplitude [1]. Iron oxides magnetite Fe3O4 and maghemite γ-Fe2O3 nanoparticles are the most studied to date [2] due to their biocompatibilty [3] for hyperthermia application. The heat generated by the particles when exposed to an external alternating magnetic field is mainly due to the Néel relaxation mechanism and/or Brownian motion of the particles [4]. The superparamagnetic particles (10–40 nm) are recommended in clinical application as they are able to generate substantial heat within a small magnetic field strength and frequency [5].

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