Poroelastic or biphasic models have been used to study hydrocephalus  and the fluid transport that occurs during positive pressure infusion, also called convection enhanced delivery [2,3]. Each of the studies is limited by the assumption of linear elasticity of the solid phase. Nonlinear stress-strain curves under finite deformations have been documented for brain tissue under tension  and compression . The nonlinear variation of hydraulic conductivity with strain has also recently been taken into account [1,3] and this effect has been deemed to play an important role in both the mechanics of the tissue and the associated fluid transport.
Volume Subject Area:Biomass Transfer Processes in Tissues
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