Despite recent progress, mechanical properties of tissue engineered heart valves still lack mechanical strength compared to native aortic valves [1]. Although cyclic tissue straining in bioreactor systems is known to enhance tissue formation [2], specific optimal loading protocols have not yet been defined. To get a better insight in the effects of mechanical loading on tissue development, mechanical behavior of tissue constructs should be monitored and controlled during culture. However, currently used methods for mechanical characterization (e.g. tensile tests, indentation tests) are destructive and can therefore only be performed at the end stage of tissue culture. An experimental-numerical approach was previously proposed by which leaflet deformation was assessed during culture in a bioreactor system, real-time and non-invasively [3]. Further development of this approach now enables a non-invasive and non-destructive assessment of mechanical properties of engineered heart valve leaflets.
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Non-Destructive and Non-Invasive Assessment of Mechanical Properties in Heart Valve Tissue Engineering Available to Purchase
Jeroen Kortsmit,
Jeroen Kortsmit
Technical University of Eindhoven, Eindhoven, The Netherlands
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Niels J. B. Driessen,
Niels J. B. Driessen
Technical University of Eindhoven, Eindhoven, The Netherlands
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Marcel C. M. Rutten,
Marcel C. M. Rutten
Technical University of Eindhoven, Eindhoven, The Netherlands
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Frank P. T. Baaijens
Frank P. T. Baaijens
Technical University of Eindhoven, Eindhoven, The Netherlands
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Jeroen Kortsmit
Technical University of Eindhoven, Eindhoven, The Netherlands
Niels J. B. Driessen
Technical University of Eindhoven, Eindhoven, The Netherlands
Marcel C. M. Rutten
Technical University of Eindhoven, Eindhoven, The Netherlands
Frank P. T. Baaijens
Technical University of Eindhoven, Eindhoven, The Netherlands
Paper No:
SBC2008-192799, pp. 135-136; 2 pages
Published Online:
March 13, 2014
Citation
Kortsmit, J, Driessen, NJB, Rutten, MCM, & Baaijens, FPT. "Non-Destructive and Non-Invasive Assessment of Mechanical Properties in Heart Valve Tissue Engineering." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 135-136. ASME. https://doi.org/10.1115/SBC2008-192799
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