Mitral valve (MV) disease affects millions worldwide. An important goal of present-day heart valve research is to create bioengineered tissue valves to replace diseased mitral valves, if it is judged that mitral repair will not be durable. The design of such valves will pivot on understanding the stresses acting in the native MV leaflets to design a bioprosthesis which will withstand these stresses. In order to quantify such stresses in vivo, we utilized radiopaque marker technology and performed an “inverse” finite element analysis of the resulting 4-D data to determine the material properties of the anterior MV leaflet in the beating ovine heart. We then used these material properties in a “forward” finite element analysis to estimate the stresses in the native anterior MV leaflet.
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Quantification of In Vivo Stresses in the Ovine Anterior Mitral Valve Leaflet
Gaurav Krishnamurthy,
Gaurav Krishnamurthy
Stanford University, Stanford, CA
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Akinobu Itoh,
Akinobu Itoh
Stanford University, Stanford, CA
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Wolfgang Bothe,
Wolfgang Bothe
Stanford University, Stanford, CA
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Daniel B. Ennis,
Daniel B. Ennis
Stanford University, Stanford, CA
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Julia C. Swanson,
Julia C. Swanson
Stanford University, Stanford, CA
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D. Craig Miller,
D. Craig Miller
Stanford University, Stanford, CA
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Neil B. Ingels
Neil B. Ingels
Stanford University, Stanford, CA
Research Institute of the Palo Alto Medical Foundation, Palo Alto, CA
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Gaurav Krishnamurthy
Stanford University, Stanford, CA
Akinobu Itoh
Stanford University, Stanford, CA
Wolfgang Bothe
Stanford University, Stanford, CA
Daniel B. Ennis
Stanford University, Stanford, CA
Julia C. Swanson
Stanford University, Stanford, CA
Ellen Kuhl
Stanford University, Stanford, CA
D. Craig Miller
Stanford University, Stanford, CA
Neil B. Ingels
Stanford University, Stanford, CA
Research Institute of the Palo Alto Medical Foundation, Palo Alto, CA
Paper No:
SBC2008-192295, pp. 131-132; 2 pages
Published Online:
March 13, 2014
Citation
Krishnamurthy, G, Itoh, A, Bothe, W, Ennis, DB, Swanson, JC, Kuhl, E, Miller, DC, & Ingels, NB. "Quantification of In Vivo Stresses in the Ovine Anterior Mitral Valve Leaflet." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 131-132. ASME. https://doi.org/10.1115/SBC2008-192295
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