Reduced nucleus pulposus glycosaminoglycan (GAG) content is one of the earliest clinically detectable changes during the course of intervertebral disc degeneration [1,2]. Depletion of nucleus GAG by small percentages consistent with this early loss has been experimentally linked to altered motion segment mechanical function, and thus, potentially increases the risk of damage accumulation directly due to elevated stresses and strains and through altered cellular function [3]. Recently, our laboratory has established an in vivo model in a rat lumbar disc which moderately decreases nucleus GAG to levels observed in early human degeneration. In this model, GAG loss is accompanied by a state of hypermobility at both 4 and 12 weeks post treatment [4], potentially making the disc susceptible to mechanical failure. The objective of this study was to determine the long term effects of nucleus GAG depletion and to determine if altered discs demonstrate hallmark features of disc degeneration. We hypothesized that GAG will remain depleted 24 weeks post treatment, potentially decreasing to lower levels, and further that geometrical and mechanical changes consistent with degeneration will be observed.
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Intervertebral Disc Function Is Restored in an In Vivo Model of Chronic Nucleus Pulposus Glycosaminoglycan Reduction
John I. Boxberger,
John I. Boxberger
University of Pennsylvania, Philadelphia, PA
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Joshua D. Auerbach,
Joshua D. Auerbach
University of Pennsylvania, Philadelphia, PA
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Sounok Sen,
Sounok Sen
University of Pennsylvania, Philadelphia, PA
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George R. Dodge,
George R. Dodge
Alfred I. duPont Hospital for Children, Wilmington, DE
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Dawn M. Elliott
Dawn M. Elliott
University of Pennsylvania, Philadelphia, PA
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John I. Boxberger
University of Pennsylvania, Philadelphia, PA
Joshua D. Auerbach
University of Pennsylvania, Philadelphia, PA
Sounok Sen
University of Pennsylvania, Philadelphia, PA
George R. Dodge
Alfred I. duPont Hospital for Children, Wilmington, DE
Dawn M. Elliott
University of Pennsylvania, Philadelphia, PA
Paper No:
SBC2008-192937, pp. 127-128; 2 pages
Published Online:
March 13, 2014
Citation
Boxberger, JI, Auerbach, JD, Sen, S, Dodge, GR, & Elliott, DM. "Intervertebral Disc Function Is Restored in an In Vivo Model of Chronic Nucleus Pulposus Glycosaminoglycan Reduction." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 127-128. ASME. https://doi.org/10.1115/SBC2008-192937
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