It has been shown that precise microarchitecture and surface microtexture can enhance cell behavior such as cell attachment, proliferation, migration and differentiation in cell culture environment [1]. Even though Polydimethylsiloxane (PDMS) has been commonly used to fabricate the microtextured surfaces, PDMS is not biodegradable. Cellulose Acetate (CA), on the other hand, has very promising properties as scaffold material for tissue engineering applications. It is biodegradable, has low water solubility, and generates minimal foreign body reaction in vivo [2]. In this study, soft lithography techniques are used to fabricate CA and PDMS scaffolds with precise surface microtextures to compare growth characteristics of progenitor cells.

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