Vertebral fractures are among the most common and debilitating fractures. Structural organization of cancellous and cortical bone in a vertebra and their local properties are important factors that determine the strength of a vertebra. Linear finite element models utilizing Quantitative Computed Tomography (QCT) images have proven useful for predicting vertebral strength and are potentially useful in predicting risk of fracture in a clinical setting [1]. However, the amount of architectural detail in these models is not sufficient for studying trabecular stress and strains, and their relationship with the microscopic structure, which is important for understanding the mechanisms behind vertebral fragility.

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