Local delivery of a drug in vivo would permit high interstitial drug concentration at the desired location without producing high systemic drug levels. Previous local drug delivery systems have included biodegradable polymer implants, hydrogels, and osmotic pumps [1]. In this paper, we describe a novel local drug delivery system using nordihydroguaiaretic acid (NDGA)-polymerized collagen fibers. NDGA collagen fibers were originally developed for use as biocompatible tendon bioprostheses [2]. The NDGA collagen fibers were loaded with either: dexamethasone, a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities; or dexamethasone 21-phosphate, a water soluble pro-drug that is converted into dexamethasone in vivo. Dexamethasone was chosen as the loading agent since experiments pairing the loaded fibers with implantable glucose sensors will be performed in the future. This may be useful for preventing inflammation around implantable glucose sensor [3]. This decrease in inflammation is expected to increase glucose sensor function and lifetime. We also determined the diffusion coefficient of dexamethasone and dexamethasone 21-phosphate in the NDGA collagen fiber. In an effort to control the rate of release of dexamethasone, the biocompatible copolymer, polylactic-co-glycolic acid (PLGA) was used to coat the fibers. The information obtained from these experiments is necessary for the future development of an optimal local delivery system of dexamethasone using NDGA collagen fibers in an effort to suppress the inflammatory response around implantable glucose sensors.
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Transport Characteristics of a Novel Local Drug Delivery System Using Nordihydroguaiaretic Acid (NDGA)-Polymerized Collagen Fibers
Eric Guegan,
Eric Guegan
University of South Florida, Tampa, FL
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Tian Davis,
Tian Davis
University of South Florida, Tampa, FL
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Thomas J. Koob,
Thomas J. Koob
University of South Florida, Tampa, FL
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Yvonne Moussy
Yvonne Moussy
University of South Florida, Tampa, FL
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Eric Guegan
University of South Florida, Tampa, FL
Tian Davis
University of South Florida, Tampa, FL
Thomas J. Koob
University of South Florida, Tampa, FL
Yvonne Moussy
University of South Florida, Tampa, FL
Paper No:
SBC2007-171428, pp. 93-94; 2 pages
Published Online:
March 12, 2014
Citation
Guegan, E, Davis, T, Koob, TJ, & Moussy, Y. "Transport Characteristics of a Novel Local Drug Delivery System Using Nordihydroguaiaretic Acid (NDGA)-Polymerized Collagen Fibers." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 93-94. ASME. https://doi.org/10.1115/SBC2007-171428
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