Convection-enhanced delivery (CED) is a promising drug delivery method for treating diseases of the brain and spinal cord. CED infuses therapeutic agents via a cannula directly into the intraparenchymal space, circumventing the blood–brain barrier (BBB) and improving drug targeting . CED enhances the transport of macromolecules by introducing convective transport to supplement diffusive transport.
Effects of Tissue Swelling on Macromolecular Transport in Nervous Tissue: A Simulation Analysis
Chen, X, & Sarntinoranont, M. "Effects of Tissue Swelling on Macromolecular Transport in Nervous Tissue: A Simulation Analysis." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 903-904. ASME. https://doi.org/10.1115/SBC2007-176252
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