The attainment of specific design goals related to tissue structure and function is likely critical to the development of a consistently successful strategy for articular cartilage (AC) repair. The long-term goal of this research is to develop a cartilage growth mixture (CGM) model that may be used with experimental approaches to improve AC repair strategies. The CGM employs a “stress balance” hypothesis: at equilibrium, the crosslinked collagen (COL) network restrains the proteoglycan (PG) swelling pressure generated by fixed charge density. The specific objectives are to: 1) refine a previous CGM model  to include COL remodeling; 2) develop analytical protocols for model validation that are based on experimental data from select in vitro growth protocols; and 3) test CGM model hypotheses.
A Cartilage Growth Mixture Model With Collagen Remodeling: Validation Protocols
Klisch, SM, Asanbaeva, A, Oungoulian, SR, Thonar, EJA, Masuda, K, Davol, A, & Sah, RL. "A Cartilage Growth Mixture Model With Collagen Remodeling: Validation Protocols." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 861-862. ASME. https://doi.org/10.1115/SBC2007-175548
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