The Wnt/β-Catenin signaling pathway is a key regulator in bone development and bone homeostasis. Inactivating mutations in the Wnt co-receptor Low density lipoprotein Receptor related Protein 5 (LRP5) results in osteoporosis while “activating” mutations in LRP5 results in high bone mass. Dickkopf-1 (Dkk1) is a secreted Wnt inhibitor that binds to LRP5 and LRP6 reducing their availability to form a complex with Wnt and Frizzled and resulting in unrestrained Wnt signaling. It is expected that a decrease in Dkk1 will result in an increase in Wnt activity and ultimately a high bone mass phenotype. An allelic series of Dkk1 mutant mice were generated to examine the affects of reduced Dkk1 levels on bone density, morphology, and mechanical properties.
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Reduction of the Wnt Inhibitor Dkk1 Correlates With Improved Bone Mechanical and Morphological Properties in Mice
Danese M. Joiner,
Danese M. Joiner
University of Michigan, Ann Arbor, MI
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Bryan T. MacDonald,
Bryan T. MacDonald
Harvard Medical School, Boston, MA
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Peter V. Hauschka,
Peter V. Hauschka
Harvard Medical School, Boston, MA
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Steven A. Goldstein
Steven A. Goldstein
University of Michigan, Ann Arbor, MI
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Danese M. Joiner
University of Michigan, Ann Arbor, MI
Bryan T. MacDonald
Harvard Medical School, Boston, MA
Xi He
Harvard Medical School, Boston, MA
Peter V. Hauschka
Harvard Medical School, Boston, MA
Steven A. Goldstein
University of Michigan, Ann Arbor, MI
Paper No:
SBC2007-175478, pp. 859-860; 2 pages
Published Online:
March 12, 2014
Citation
Joiner, DM, MacDonald, BT, He, X, Hauschka, PV, & Goldstein, SA. "Reduction of the Wnt Inhibitor Dkk1 Correlates With Improved Bone Mechanical and Morphological Properties in Mice." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 859-860. ASME. https://doi.org/10.1115/SBC2007-175478
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