A Mechanical and Computational Investigation on the Effects of Conduit Orientation on the Strength of Massive Bone Allografts

Massive allograft bone is the primary source of bone graft material for use in limb salvage procedures after oncological tumor resection. However, allograft bone has been found to incorporate slowly into host bone resulting in allograft susceptibility to non-union, fracture, infection and fatigue failure. Clinical studies have shown that massive allograft bone has a 50% to 75% success rate at 10 years [1].