Multiple urinary bladder wall (UBW) pathologies, such as overactive bladder, bladder outlet obstruction, spinal cord injury (SCI) and related neurogenic disorders, and diabetes result in tissue remodeling marked by hypertrophic bladder smooth muscle cells (BSMC) and altered extra-cellular matrix components. This remodeling results in changes in UBW biomechanical properties leading to altered bladder function. Our previous studies have revealed that during the initial areflexic phase of SCI the UBW undergoes profound remodeling that appears to be a compensatory mechanism for the increased wall stretch resulting from over-distension [1, 2]. Remodeling in the bladder wall results in changes in biomechanics and ultimately the ability of the organ to normally fill and void [3]. The stimuli and precise mechanisms that are responsible for bladder remodeling in SCI and the aforementioned pathologies remain unknown. The objective of the present study is to determine the effects of varied in vitro strain on ECM production in the ex vivo rat bladder as a first step toward understanding tissue remodeling in response to strain.
Skip Nav Destination
ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Strain Induced Bladder Smooth Muscle Remodeling
Rebecca A. Long,
Rebecca A. Long
University of Pittsburgh, Pittsburgh, PA
Search for other works by this author on:
Aron Parekh,
Aron Parekh
University of Pittsburgh, Pittsburgh, PA
Search for other works by this author on:
Michael S. Sacks
Michael S. Sacks
University of Pittsburgh, Pittsburgh, PA
Search for other works by this author on:
Rebecca A. Long
University of Pittsburgh, Pittsburgh, PA
Aron Parekh
University of Pittsburgh, Pittsburgh, PA
Michael S. Sacks
University of Pittsburgh, Pittsburgh, PA
Paper No:
SBC2007-176289, pp. 807-808; 2 pages
Published Online:
March 12, 2014
Citation
Long, RA, Parekh, A, & Sacks, MS. "Strain Induced Bladder Smooth Muscle Remodeling." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 807-808. ASME. https://doi.org/10.1115/SBC2007-176289
Download citation file:
4
Views
Related Proceedings Papers
Related Articles
Computer Simulation of Female Urinary Incontinence
J. Med. Devices (June,2008)
Repeated High Rate Facet Capsular Stretch at Strains That are Below the Pain Threshold Induces Pain and Spinal Inflammation With Decreased Ligament Strength in the Rat
J Biomech Eng (August,2018)
The Effect of Flash Freezing on Variability in Spinal Cord Compression Behavior
J Biomech Eng (November,2009)
Related Chapters
Mechanical Properties and Modeling of the Stress-Strain Behavior of the Urinary Bladder In Vivo
Biomaterials' Mechanical Properties
Summary and future direction
Nanomaterials in Glucose Sensing: Biomedical & Nanomedical Technologies - Concise Monographs
Introduction and scope
Impedimetric Biosensors for Medical Applications: Current Progress and Challenges