Biological development is a complex and highly-regulated process, a significant part of which is controlled by mechanostimulus, or the strain imparted on a cell by its environment. Mechanostimulus is important for stem cell differentiation, from cytoskeletal assembly to cell-cell and cell-matrix adhesion . The mechanics of cells and tissues play a critical role in organisms, under both physiological and pathological conditions; abnormal mechanotransduction — the mechanism by which cells sense and respond to strain — has been implicated in a wide range of clinical pathologies [2,3].
Anisotropic Strain Effects on Vascular Smooth Muscle Cell Physiology
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Tsvankin, V, Belchenko, D, Scott, D, & Tan, W. "Anisotropic Strain Effects on Vascular Smooth Muscle Cell Physiology." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 805-806. ASME. https://doi.org/10.1115/SBC2007-176284
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