In a healthy meniscus, the compressive strains are approximately 2–10%. [1] When 30% or more of the tissue is removed during partial meniscectomy, strains increase to approximately 18%. [1] We have previously shown that dynamic compressive strains of 20% to meniscal explants results in an increase in proteoglycan (PG) breakdown, nitric oxide (NO) production, metalloproteinases 1, 3, and 13 (MMP-1, MMP-3, and MMP-13) compared to 0, 5, and 10% compressive strain. [2,3,4] The objective of this study was to determine if interruption of the IL-1 pathway would alter this biochemical response to dynamic mechanical compression.

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