Previous studies have shown that bone fracture toughness is also significantly correlated to changes in porosity, microarchitecture, osteonal morphology, collagen integrity, microdamage, and the interactions of water with collagen and mineral phases, all of which are measures of bone quality. Currently, the influence of water removal on the strength and toughness of cortical bone has studied by Nyman et al . The results have shown that loss of water in the collagen phase decreases the toughness of bone, whereas loss of water associated with the mineral phase decreases both bone strength and toughness. However, in that paper the loss of water was used the dehydration method for such mechanism studies. Here, we hypothesize that the NMR relaxation technique can non-destructively and non-invasively assess the porosity, bound water (water bound to collage and mineral phases) and mobile water (water within the pores).
The Characterization of Age-Related Human Cortical Bone Porosity, Water Distribution Changes by Nuclear Magnetic Resonance
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Ni, Q, Nyman, JS, Wang, X, & Nicolella, DP. "The Characterization of Age-Related Human Cortical Bone Porosity, Water Distribution Changes by Nuclear Magnetic Resonance." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 7-8. ASME. https://doi.org/10.1115/SBC2007-176213
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