Orofacial pain associated with osteoarthritis (OA) in the temporomandibular joint (TMJ) is a significant clinical problem [1]. The pathophysiologic and cellular mediators that underlie the development of such chronic orofacial pain are not well understood, nor has a relationship to mechanical loading been defined. Several experimental models have been developed to examine causative factors in TMJ OA progression and joint pathology. Such models often involve intra-articular injections or surgical manipulation of tissue structures in order to alter joint kinematics and stability [2–6]. For example, severing of the discal attachments followed by anterior displacement of the disc has been employed in a rabbit model, while disc perforation and scraping of the condylar surface have been used in sheep models to induce OA symptoms [2,3]. A limitation of the above approaches is that they introduce artificial damage to the joint structures and do not approximate the clinical disorder of mechanically-induced TMJ OA. Therefore, the goal of this pilot study was to develop a novel model of TMJ OA via non-invasive and mechanically relevant methods that could produce behavioral hypersensitivity (mechanical allodynia) suggestive of pain symptoms and histological changes in the TMJ consistent with osteoarthritic pathology.
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
A Rat Model of Osteoarthritic Temporomandibular Joint Pain: Mechanically-Induced Behavioral Hypersensitivity and Histologic Modifications
Steven B. Nicoll,
Steven B. Nicoll
University of Pennsylvania, Philadelphia, PA
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Christopher K. Hee,
Christopher K. Hee
University of Pennsylvania, Philadelphia, PA
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Martin B. Davis,
Martin B. Davis
University of Pennsylvania, Philadelphia, PA
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Beth A. Winkelstein
Beth A. Winkelstein
University of Pennsylvania, Philadelphia, PA
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Steven B. Nicoll
University of Pennsylvania, Philadelphia, PA
Christopher K. Hee
University of Pennsylvania, Philadelphia, PA
Martin B. Davis
University of Pennsylvania, Philadelphia, PA
Beth A. Winkelstein
University of Pennsylvania, Philadelphia, PA
Paper No:
SBC2007-176520, pp. 651-652; 2 pages
Published Online:
March 12, 2014
Citation
Nicoll, SB, Hee, CK, Davis, MB, & Winkelstein, BA. "A Rat Model of Osteoarthritic Temporomandibular Joint Pain: Mechanically-Induced Behavioral Hypersensitivity and Histologic Modifications." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 651-652. ASME. https://doi.org/10.1115/SBC2007-176520
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