A BioMEMS platform was designed and fabricated to enable electromechanical stimulation of cell cultures. The device consists of a stretchable microelectrode array embedded in a biocompatible elastomeric polymer, which is deformed by vacuum over a glass baseplate. The entire device is optically transparent and ∼1mm thick. Four cell culture wells apply electrical and/or mechanical stimulation in the range of 1–10 V/cm and 0–10% equibiaxial strain. Studies of electromechanical stimulation of cardiac myocyte precursors on this platform are proposed to elucidate mechanisms of differentiation.
BioMEMS Platform for Electromechanical Stimulation of Cell Culture
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Blundo, J, Chua, G, Abilez, O, Park, Y, Rastegar, A, Cao, F, Zarins, C, Wu, J, & Pruitt, B. "BioMEMS Platform for Electromechanical Stimulation of Cell Culture." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 63-64. ASME. https://doi.org/10.1115/SBC2007-176716
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