The human cerebral cortex undergoes folding from the 5th fetal month into the first post-natal year. Disturbances of folding have serious and lasting consequences, but the mechanism is not well understood. Van Essen [1] has hypothesized that axonal tension between strongly interconnected regions draws them together and induces outward folds. However, no direct measurements have confirmed this theory. Experimental data are needed, beginning with a quantitative description of the kinematics of cortical growth during folding.
Volume Subject Area:
Imaging in Biomechanics
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