Vascular hemodynamic forces influence the focal development of atherosclerosis. Atherogenesis has been linked to low and oscillating wall shear stress (WSS) driven by the pulsatile nature of blood flow [1, 2]. Strong evidence has emerged that time-averaged WSS (TAWSS) and oscillating shear index (OSI) are important measures of the atherogenic nature of blood flow. Recently it was reported that the phase-angle between oscillating WSS and circumferential strain in arterial wall (stress phase angle: SPA) may also influence endothelial cell function and contribute to atherosclerosis [3]. In stenosed, curved or bifurcated arteries, the blood flow pattern is complex because of flow separation, which is highly sensitive to the local velocity waveform [4]. Although the effects of waveform on coronary blood flow has been studied by comparing physiological and idealised waveforms [5], the effects of variation in physiological waveforms and their impact on SPA are still unclear. In this study we investigated computationally the influence of physiological flow velocity and pressure waveforms on coronary hemodynamic parameters (e.g. TAWSS, OSI and SPA) using waveforms acquired before and after coronary artery stenting.
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Does the Difference in Realistic Waveform Before and After Stenting Affect Hemodynamics in Stenosed Coronary Artery?
Nearchos Hadjiloizou,
Nearchos Hadjiloizou
St. Mary’s Hospital and Imperial College, London, UK
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Andrew Wright,
Andrew Wright
St. Mary’s Hospital and Imperial College, London, UK
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Alun D. Hughes,
Alun D. Hughes
St. Mary’s Hospital and Imperial College, London, UK
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Simon A. M. Thom,
Simon A. M. Thom
St. Mary’s Hospital and Imperial College, London, UK
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X. Yun Xu
X. Yun Xu
Imperial College, London, UK
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Ryo Torii
Imperial College, London, UK
Nigel B. Wood
Imperial College, London, UK
Nearchos Hadjiloizou
St. Mary’s Hospital and Imperial College, London, UK
Andrew Wright
St. Mary’s Hospital and Imperial College, London, UK
Alun D. Hughes
St. Mary’s Hospital and Imperial College, London, UK
Simon A. M. Thom
St. Mary’s Hospital and Imperial College, London, UK
X. Yun Xu
Imperial College, London, UK
Paper No:
SBC2007-176150, pp. 467-468; 2 pages
Published Online:
March 12, 2014
Citation
Torii, R, Wood, NB, Hadjiloizou, N, Wright, A, Hughes, AD, Thom, SAM, & Xu, XY. "Does the Difference in Realistic Waveform Before and After Stenting Affect Hemodynamics in Stenosed Coronary Artery?." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 467-468. ASME. https://doi.org/10.1115/SBC2007-176150
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