Mechanical forces play an important role in the complicated process of atherosclerotic plaque rupture which often leads to serious clinical events such as stroke and heart attack . Factors causing the vulnerable plaque cap to fracture are important clinically [2–7]. It is known that coronary plaques are more likely to rupture compared to carotid plaques under comparable conditions (such as stenosis severity at about 50% by diameter). One possible reason is that coronary arteries are under cyclic bending caused by heart motions and compressions. We hypothesize that cyclic bending of coronary atherosclerotic plaques may be a major contributor to critical stress variations in the plaque leading to increased plaque rupture risk. We have developed MRI-based 3D multi-component models with fluid-structure interactions (FSI) in order to perform flow and stress/strain analysis for atherosclerotic plaques and identify possible mechanical and morphological indices for accurate plaque vulnerability assessment [6–7].
Cyclic Bending of Coronary Plaques Leads to Much Higher Stress Variations: A Major Factor Contributing to Plaque Rupture Risk
Tang, D, Yang, C, Zheng, J, Kobayashi, S, Sicard, GA, Woodard, PK, & Ku, DN. "Cyclic Bending of Coronary Plaques Leads to Much Higher Stress Variations: A Major Factor Contributing to Plaque Rupture Risk." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 453-454. ASME. https://doi.org/10.1115/SBC2007-175454
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