The complex loading of the knee is believed to play an extensive role in the development and advancement of joint disease and injury. Computational models provide a powerful tool in knee biomechanics, but validation of these models is difficult. The objective of this study was to develop a dynamic 3-D subject-specific computational knee model and to validate the model using experimental data from a dynamic knee simulator. The developed knee model was placed in a previously validated model of the Kansas Knee Simulator (KKS) dynamic testing machine [1]. The kinematics from walking and squat profiles simulated in the KKS model and performed on the knee specimen during KKS experimental testing were compared for model validation.

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