To appropriately tissue engineer load-bearing soft tissues requires reproducing the tissues mechanical structure. The most important mechanical component is collagen, which forms a cross-linked fiber network. Soft tissues adapt their structures to their functions, by aligning the predominant fiber orientation with the loading direction.
A New Versatile Mechanistic Collagen Remodeling Algorithm
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van Donkelaar, CC, & Wilson, W. "A New Versatile Mechanistic Collagen Remodeling Algorithm." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 363-364. ASME. https://doi.org/10.1115/SBC2007-176303
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