One key issue in clinical, non-invasive assessment of bone quality and fracture risk is the accurate prediction of localized trabecular strength through the determination of peak stress values and locations. Additionally, it has been suggested that peak stress/strain concentrations may play an important role in driving the bone remodeling process. Micro-CT based voxel finite element (FE) meshes have been widely used in nondestructive evaluation of global stiffness. Subsequently, this technique has been advantageous in studies addressing changes in bone volume and microstructure.

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