We have previously developed a cell culture model to study the effects of angiogenic factors, such as sphingosine-1-phosphate (S1P), on the invasion of endothelial cells into the underlying extracellular matrix. In addition to biochemical stimuli, vascular endothelial cells are subjected to fluid shear stress due to blood flow. The present study is aimed at determining the effects of fluid shear stress on endothelial cell invasion into collagen gels. A device was constructed to apply well-defined fluid shear stresses to confluent human umbilical vein endothelial cells (HUVECs) seeded on collagen gels. Fluid shear stress induced significant increases in cell invasion with a maximal induction at ∼5 dyn/cm2. These results provide evidence that fluid shear stress is a significant stimulus for endothelial cell invasion and may play a role in regulating angiogenesis.
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Effects of Fluid Shear Stress on Endothelial Cell Invasion Into Three-Dimensional Matrices
Hojin Kang,
Hojin Kang
Texas A&M University, College Station, TX
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Kayla J. Bayless,
Kayla J. Bayless
Texas A&M University, College Station, TX
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Roland Kaunas
Roland Kaunas
Texas A&M University, College Station, TX
Search for other works by this author on:
Hojin Kang
Texas A&M University, College Station, TX
Kayla J. Bayless
Texas A&M University, College Station, TX
Roland Kaunas
Texas A&M University, College Station, TX
Paper No:
SBC2007-176207, pp. 287-288; 2 pages
Published Online:
March 12, 2014
Citation
Kang, H, Bayless, KJ, & Kaunas, R. "Effects of Fluid Shear Stress on Endothelial Cell Invasion Into Three-Dimensional Matrices." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 287-288. ASME. https://doi.org/10.1115/SBC2007-176207
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