Soft media like hydrogels are used as substrates for cellular engineering of different cell types and the stiffness of these media plays an important role in the cellular behavior like adhesion, proliferation, matrix deposition and differentiation. The global mechanical properties of such substrates were previously calculated using spherical beads embedded in micro-liter samples and then deflecting them by a magnetic manipulator [1]. Knowing the force and the displacement the elastic modulus was evaluated using closed form solutions. However in the context of our studies for biological applications there are circumstances where the local elastic properties of the hydrogel play an important role. For example in the vicinity of a cell, the cell will distort the gel and the modulus of elasticity of the surface may get altered, particularly if the gel is non-linear and if the distortions are substantial. In order to measure these local properties a four magnet manipulator based on Amblard, et al [2] was built, which is capable of applying large forces on micron sized particles embedded in the media.
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Force/Torque Field Generation to Obtain Local Properties within Soft Hydrogels
Uday Chippada,
Uday Chippada
Rutgers University, Piscataway, NJ
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Bernard Yurke,
Bernard Yurke
Alcatel-Lucent, Murray Hill, NJ
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David I. Shreiber,
David I. Shreiber
Rutgers University, Piscataway, NJ
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Rene Schloss,
Rene Schloss
Rutgers University, Piscataway, NJ
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Noshir A. Langrana
Noshir A. Langrana
Rutgers University, Piscataway, NJ
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Uday Chippada
Rutgers University, Piscataway, NJ
Bernard Yurke
Alcatel-Lucent, Murray Hill, NJ
David I. Shreiber
Rutgers University, Piscataway, NJ
Rene Schloss
Rutgers University, Piscataway, NJ
Xue Jiang
Rutgers University, Piscataway, NJ
Lulu Li
Rutgers University, Piscataway, NJ
Noshir A. Langrana
Rutgers University, Piscataway, NJ
Paper No:
SBC2007-176081, pp. 257-258; 2 pages
Published Online:
March 12, 2014
Citation
Chippada, U, Yurke, B, Shreiber, DI, Schloss, R, Jiang, X, Li, L, & Langrana, NA. "Force/Torque Field Generation to Obtain Local Properties within Soft Hydrogels." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 257-258. ASME. https://doi.org/10.1115/SBC2007-176081
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