In the heart aortic valve, maintenance of healthy conditions and transition to diseased conditions are modulated by the cells in the valve. The cells found within the valve leaflets and walls are the valvular interstitial cells (VICs), and those found on the fluid-facing surfaces are the endothelial cells (ECs). Both types of cell are known to respond to their mechanical state; that is, the stresses and deformations imposed on the cell by its surrounding environment. Here, we present a set of simulations to examine the mechanical states of cells as the valve goes through its opening and closing cycle. The simulations span the cell, tissue, and organ length scales. Taken together, these simulations predict the dynamic, three-dimensional mechanical state of VICs and ECs throughout the valve.
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Multiscale Fluid-Structure Simulations of the Aortic Valve Available to Purchase
Eli Weinberg,
Eli Weinberg
Massachusetts Institute of Technology, Cambridge, MA
Draper Laboratory, Cambridge, MA
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Mohammad Mofrad
Mohammad Mofrad
University of California, Berkeley, Berkeley, CA
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Eli Weinberg
Massachusetts Institute of Technology, Cambridge, MA
Draper Laboratory, Cambridge, MA
Mohammad Mofrad
University of California, Berkeley, Berkeley, CA
Paper No:
SBC2007-176730, pp. 245-246; 2 pages
Published Online:
March 12, 2014
Citation
Weinberg, E, & Mofrad, M. "Multiscale Fluid-Structure Simulations of the Aortic Valve." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 245-246. ASME. https://doi.org/10.1115/SBC2007-176730
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