While documented risk factors (e.g., hypertension, diabetes, etc.) for atherosclerosis are systemic in nature, atherosclerotic plaques appear in a heterogeneous distribution in the vasculature [1]. Certain arteries (e.g., coronary arteries) are exposed to cyclic deformations such as stretching, bending, and twisting due to their being tethered to surrounding tissue beds [2]. Such stimuli likely results in spatially-varying biomechanical stresses and may be a key modulator of atherosclerotic lesion localization [3]. We have developed a unique methodology for combining ex vivo experimental perfusion of arterial segments with computational modeling. Using this methodology we examined the hypothesis that local variations in shear and mural stress associated with cyclic axial stretch of arterial segments influence the distribution of endothelial permeability and the expression of various genes associated with atherogenesis.
Skip Nav Destination
ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Biological Markers of Atherogenesis Correlate With Both Shear and Mural Stress in Perfused Arterial Segments Exposed to Cyclic Axial Stretching Ex Vivo
J. Scott VanEpps,
J. Scott VanEpps
University of Pittsburgh, Pittsburgh, PA
Search for other works by this author on:
Douglas W. Chew,
Douglas W. Chew
University of Pittsburgh, Pittsburgh, PA
Search for other works by this author on:
David A. Vorp
David A. Vorp
University of Pittsburgh, Pittsburgh, PA
Search for other works by this author on:
J. Scott VanEpps
University of Pittsburgh, Pittsburgh, PA
Douglas W. Chew
University of Pittsburgh, Pittsburgh, PA
David A. Vorp
University of Pittsburgh, Pittsburgh, PA
Paper No:
SBC2007-176674, pp. 235-236; 2 pages
Published Online:
March 12, 2014
Citation
VanEpps, JS, Chew, DW, & Vorp, DA. "Biological Markers of Atherogenesis Correlate With Both Shear and Mural Stress in Perfused Arterial Segments Exposed to Cyclic Axial Stretching Ex Vivo." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 235-236. ASME. https://doi.org/10.1115/SBC2007-176674
Download citation file:
4
Views
Related Proceedings Papers
Related Articles
A New Three-Dimensional Exponential Material Model of the Coronary Arterial Wall to Include Shear Stress Due to Torsion
J Biomech Eng (October,2008)
Computational Modeling of LDL and Albumin Transport in an In Vivo CT Image-Based Human Right Coronary Artery
J Biomech Eng (February,2009)
Related Chapters
Introduction
Ultrasonic Methods for Measurement of Small Motion and Deformation of Biological Tissues for Assessment of Viscoelasticity
Basic Features
Structural Shear Joints: Analyses, Properties and Design for Repeat Loading
Numerical Simulation of Spatial Synergic Interaction in the Double-Row Anti-Sliding Piles
Geological Engineering: Proceedings of the 1 st International Conference (ICGE 2007)