Under normal physiological conditions platelets circulate in the plasma of blood and respond to vessel injury by changing shape, secreting granule contents and aggregating [1]. The activation of platelets in diseased or occluded arteries can form thrombosis causing a heart attack or stroke [2]. Shear stress activation has been suggested as an important contributor to increased platelet activation and adhesion seen in regions of stenosis.
Volume Subject Area:
Cardiovascular Mechanics
Topics:
Platelets,
Shear stress,
Adhesion,
Blood,
Physiology,
Plasmas (Ionized gases),
Shapes,
Thrombosis,
Vessels,
Wounds
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