The mechanics of healing myocardial infarcts are an important determinant of post-infarction left ventricular (LV) function and remodeling. Large animal infarct models are well studied; healing infarct scars have been shown to be mechanically and structurally anisotropic , and this anisotropy may help preserve LV function during some stages of healing . At the same time, it has been suggested that the rat model of myocardial infarction is more similar to humans in the range of infarct sizes and observed LV dysfunction . However, in the rat model, infarct mechanics and their effect on the overall LV function have not been described so far.
Evolution of Scar Mechanical Properties During Myocardial Infarct Healing in Rat
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Fomovsky, GM, & Holmes, JW. "Evolution of Scar Mechanical Properties During Myocardial Infarct Healing in Rat." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 197-198. ASME. https://doi.org/10.1115/SBC2007-176422
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