Contemporary tissue engineered heart valves seem to have sufficient mechanical strength for implantation . Nevertheless, mechanical properties, tissue structure and architecture still need to be improved. Recent studies indicate enhancement of mechanical properties by applying cyclic diastolic pressure loads to the developing tissue in a bioreactor system . However, current bioreactors operate with a preset transvalvular pressure applied to the tissue. Mechanical properties of the engineered construct may vary during culturing and consequently, the pressure-induced deformations are unknown. To systematically study the effects of mechanical straining on tissue development and to design an optimal conditioning protocol, real-time measurement and control of local tissue strains are desired.
Non Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering
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Kortsmit, J, Driessen, NJB, Rutten, MCM, & Baaijens, FPT. "Non Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 143-144. ASME. https://doi.org/10.1115/SBC2007-175643
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