A common theme in tissue engineering and cell and tissue biomechanics is how the mechanical properties of individual tissue components or embedded cellular structures influence the continuum mechanical behavior of a tissue or construct. Meshless methods provide a useful and convenient computational framework for answering these questions [1], allowing predictions of both the effective mechanical properties of constructs and the local stresses and strains at the level of the cell. Our research focuses on understanding the mechanics of angiogenic microvessels embedded in surrogate extracellular matrix (ECM) materials [1–4]. As a first step toward understanding the interface interactions between microvessels and the ECM, the objectives of this study were to use the material point method (MPM) to analyze models of surrogate microvessels embedded in collagen gel and investigate the effects of microvessel volume fraction and interface conditions between the surrogate vessels and the collagen gel.
Skip Nav Destination
ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Effects of Interface Conditions and Volume Fraction on the Apparent Stiffness of Surrogate Multicellular Constructs Available to Purchase
Brian A. Birchler,
Brian A. Birchler
University of Utah, Salt Lake City, UT
Search for other works by this author on:
James E. Guilkey,
James E. Guilkey
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Benjamin J. Ellis,
Benjamin J. Ellis
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Steve Maas,
Steve Maas
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Jeffrey A. Weiss
Jeffrey A. Weiss
University of Utah, Salt Lake City, UT
Search for other works by this author on:
Brian A. Birchler
University of Utah, Salt Lake City, UT
James E. Guilkey
University of Utah, Salt Lake City, UT
Benjamin J. Ellis
University of Utah, Salt Lake City, UT
Steve Maas
University of Utah, Salt Lake City, UT
Jeffrey A. Weiss
University of Utah, Salt Lake City, UT
Paper No:
SBC2007-176779, pp. 1049-1050; 2 pages
Published Online:
March 12, 2014
Citation
Birchler, BA, Guilkey, JE, Ellis, BJ, Maas, S, & Weiss, JA. "Effects of Interface Conditions and Volume Fraction on the Apparent Stiffness of Surrogate Multicellular Constructs." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 1049-1050. ASME. https://doi.org/10.1115/SBC2007-176779
Download citation file:
4
Views
Related Proceedings Papers
Related Articles
Mechanical Stimulation of Tissue Engineered Tendon Constructs: Effect of Scaffold Materials
J Biomech Eng (December,2007)
Functional Tissue Engineering: The Role of Biomechanics
J Biomech Eng (December,2000)
Mechanical Characterization of Differentiated Human Embryonic Stem Cells
J Biomech Eng (June,2009)
Related Chapters
Synthesis and Characterization of Carboxymethyl Chitosan Based Hybrid Biopolymer Scaffold
International Conference on Mechanical and Electrical Technology, 3rd, (ICMET-China 2011), Volumes 1–3
In Situ Observations of the Failure Mechanisms of Hydrided Zircaloy-4
Zirconium in the Nuclear Industry: 20th International Symposium
Introduction
Ultrasonic Methods for Measurement of Small Motion and Deformation of Biological Tissues for Assessment of Viscoelasticity