Agarose has been used as an experimental scaffold for cartilage tissue engineering research due to its biocompatibility with chondrocytes, support of cartilage tissue development, and ability to transmit mechanical stimuli [1–3]. Tissue engineering studies have demonstrated that the temporal application of transforming growth factor (TGF) β3 for only 2 weeks elicits rapid tissue development that results in mechanical properties approaching native values [4]. However, it is not known whether this response to a 2-week exposure to growth factors is unique to TGF-β3. Therefore, the present study characterizes the response of tissue engineered cartilage to the temporal application of the anabolic growth factors TGF-β1, TGF-β3, and insulin-like growth factor I (IGF-I).
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
The Response of Tissue Engineered Cartilage to the Temporal Application of Transforming and Insulin-Like Growth Factors Available to Purchase
Christopher J. O’Conor,
Christopher J. O’Conor
Columbia University, New York, NY
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Kenneth W. Ng,
Kenneth W. Ng
Columbia University, New York, NY
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Lindsay E. Kugler,
Lindsay E. Kugler
Columbia University, New York, NY
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Gerard A. Ateshian,
Gerard A. Ateshian
Columbia University, New York, NY
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Clark T. Hung
Clark T. Hung
Columbia University, New York, NY
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Christopher J. O’Conor
Columbia University, New York, NY
Kenneth W. Ng
Columbia University, New York, NY
Lindsay E. Kugler
Columbia University, New York, NY
Gerard A. Ateshian
Columbia University, New York, NY
Clark T. Hung
Columbia University, New York, NY
Paper No:
SBC2007-176523, pp. 1023-1024; 2 pages
Published Online:
March 12, 2014
Citation
O’Conor, CJ, Ng, KW, Kugler, LE, Ateshian, GA, & Hung, CT. "The Response of Tissue Engineered Cartilage to the Temporal Application of Transforming and Insulin-Like Growth Factors." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 1023-1024. ASME. https://doi.org/10.1115/SBC2007-176523
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