Tissue engineering offers an attractive alternative to direct repair or reconstruction of soft tissue injuries. Tissue engineered constructs containing mesenchymal stem cells (MSCs) seeded in commercially available type I collagen sponges (P1076, Kensey Nash Corporation, Exton, PA) are currently being used within our laboratory to repair tendon injuries in rabbit models [1]. When introduced into the wound site, mechanically stimulated stem cell-collagen sponge constructs exhibit 50% greater maximum force and stiffness at 12 weeks compared to values for static controls [1]. However, these constructs often lack the maximum force sufficient to resist the peak in vivo forces acting on the repair site [2, 3]. Insufficient repair biomechanics can be attributed to the poor initial mechanical resistance provided by the collagen sponges to replace the function of the lost tendon before its degradation and replacement with new extracellular matrix. This current study seeks to identify a biologically-derived scaffold with improved mechanical integrity that could be used in stem cell-based tissue engineered constructs for tendon repair.
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Evaluation of a Novel Scaffold Material for Tendon Tissue Engineering
Victor S. Nirmalanandhan,
Victor S. Nirmalanandhan
University of Cincinnati, Cincinnati, OH
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Kirsten R. C. Kinneberg,
Kirsten R. C. Kinneberg
University of Cincinnati, Cincinnati, OH
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Natalia Juncosa-Melvin,
Natalia Juncosa-Melvin
University of Cincinnati, Cincinnati, OH
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Heather M. Powell,
Heather M. Powell
Shriners Hospitals for Children, Cincinnati, OH
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Marepalli Rao,
Marepalli Rao
University of Cincinnati, Cincinnati, OH
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Steven T. Boyce,
Steven T. Boyce
Shriners Hospitals for Children, Cincinnati, OH
University of Cincinnati, Cincinnati, OH
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David L. Butler
David L. Butler
University of Cincinnati, Cincinnati, OH
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Victor S. Nirmalanandhan
University of Cincinnati, Cincinnati, OH
Kirsten R. C. Kinneberg
University of Cincinnati, Cincinnati, OH
Natalia Juncosa-Melvin
University of Cincinnati, Cincinnati, OH
Heather M. Powell
Shriners Hospitals for Children, Cincinnati, OH
Marepalli Rao
University of Cincinnati, Cincinnati, OH
Steven T. Boyce
Shriners Hospitals for Children, Cincinnati, OH
University of Cincinnati, Cincinnati, OH
David L. Butler
University of Cincinnati, Cincinnati, OH
Paper No:
SBC2007-176294, pp. 1005-1006; 2 pages
Published Online:
March 12, 2014
Citation
Nirmalanandhan, VS, Kinneberg, KRC, Juncosa-Melvin, N, Powell, HM, Rao, M, Boyce, ST, & Butler, DL. "Evaluation of a Novel Scaffold Material for Tendon Tissue Engineering." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 1005-1006. ASME. https://doi.org/10.1115/SBC2007-176294
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